1/9/2024 0 Comments Bsa file extractor![]() ![]() 13 The finding of new drug research and development Patients are directly or indirectly attributed to drug resistance. Of chemotherapeutic drugs, and about 80–90% of deaths in cancer However, cancer cells make them resistant to nearly all types The effectiveness of these methods, there are many side effects alsoĪssociated, including fatigue, loss of appetite, weight loss, pain,Įtc. Radiotherapy and chemotherapy, hormone and gene therapy, surgery, There are different ways to treat cancer, including To 19.29 million cases and was responsible for around 9.95 millionĬancer deaths. 7− 9 According to GLOBOCAN data of 2020, the cancer burden 6Ĭancer is considered a major cause of death The blood drug concentration for a relatively long time. 4, 5 Meanwhile, BSA with a long half-life can assist drugs in improving Systems or just as protein models in numerous fundamental studies. They have great acceptance in the industry and are used as carrier 3 Most of the reported studies focused on the BSA nanoparticles since Huge variety of proteins used to prepare nanoparticles, albumin hasīeen widely utilized due to its bioavailability, nontoxicity, water-solubility,Īnd innocuous degradation metabolites. Of normally self-gathered protein subunits of a similar protein orĪ combination of proteins making up a complete framework. Nanodrug delivery platforms, which can be characterized as a substance In designing drug delivery systems has highlighted the protein-based Used in nanobiotechnology due to their favorable properties such asīiocompatibility, easy preparation and design, a variety of structures,Īnd interesting biomimetic character. 2 Nanobiopolymers such as bovine serum albumin (BSA), poly(lactic- co-glycolic acid) (PLGA), chitosan, etc., are nowadays widely 1 In the past few decades, polymeric nanoparticles have proved toīe promising agents in biomedical fields such as controlled drug/geneĭelivery, tissue engineering, cancer treatment. Particularly in the field of drug delivery. Of nanotechnology frameworks relevant in various fields of medication, Recent years, pharmaceutical research has concentrated on the improvement The ability to provide enormous chances forĪdvancing medical technologies over a wide scene of disciplines. Human cancer cell lines when compared to the noncancerous cell linesĪnd could be used as a potential candidate for anticancer agents. Nanospheres triggered ROS-dependent mitochondrial apoptosis in different Observed upon the treatment of Cp-BSA nanospheres. Gene expression level of Bax and the suppression level of Bcl-2 were ![]() An in vitro cellular uptake study was performed usingįluorescein isothiocyanate (FITC) dye at a different time of incubation,Īnd DNA fragmentation was observed in a dose-dependent manner. Oxygen species (ROS) production, and mitochondrial membrane potential In vitro, antioxidant activity using theĢ,2-diphenyl-1-picrylhydrazyl (DPPH) assay, intracellular reactive The anticancerĪctivity was evaluated on A549, HepG2, MCF-7 cancer cell lines and Polydispersity index (PDI), ζ-potential, and high entrapmentĮfficiency (82.3%) and showed sustained release of fruit extract fromĬp-BSA nanospheres in phosphate-buffered saline (PBS), pH 5. Prepared at pH 7 were spherical with a uniform particle size, low The results show that the Cp-BSA nanospheres Techniques such as dynamic light scattering (DLS), ζ-potential,įourier transform infrared spectroscopy (FTIR), and field-effect scanningĮlectron microscopy (FESEM). The nanosphere formulations were characterized using various Prepared using a desolvation method at various pH values of 5, 7,Īnd 9. Theįruit-extract-encapsulated BSA nanospheres (Cp-BSA nanospheres) were The plant extract used was the methanol fruit extract of Cucumis prophetarum, which is a medicinal herb. Present study, we synthesize bovine serum albumin (BSA) nanospheresĪnd evaluate their ability to incorporate a plant extract with anticancerĪctivity. Used as a nanocarrier for the delivery of anticancer drugs. Biodegradable polymeric nanoparticles have been
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